Safety Pharmacological Assessment Laboratory

Services

Toxicology and pharmacology study

  • Skin irritation testing (OECD 439)

The test can predict acute skin irritation of test substances (raw materials or finished products) by using Reconstructed Human Epidermis (RHE) model.

  • Skin corrosion testing (OECD 431)

The test can predict skin corrosivity of test substances (raw materials or finished products) by using Reconstructed Human Epidermis (RHE) model.

  • Skin sensitization (OECD 442)

The test can discriminate between skin sensitizers and non-sensitizers of test substances by using cell lines from immune system.

  • Photo-induced toxicity (OECD 432)

The test can determine toxic potential of test substances when exposed to light (phototoxicity) by using cultured cells.

  • Eye irritation testing (OECD 492) 

The test can predict eye irritation of test substances (raw materials or finished products) for identifying chemicals that does not cause eye irritation or serious eye damage. The testing employs Reconstructed Human Cornea-like Epithelium (HCE) model.

  • Biocompatibility and cytotoxicity testing (ISO 10993)

The test can determine biocompatibility and cytotoxicity of test substances and medical devices in various models of cultured cells and tissues.  

  • Mutagenicity or AMES test (OECD 471)

The test can determine the mutagenic potential of test substances using bacterial reverse mutation assay.

  • Anti-oxidant activity

The test measures ability in reduction of free radicals of test substances to determine their anti-oxidant activity.

  • Anti-cancer

Anti-cancer activity of test substances can be evaluated in cultured cancer cell lines.

  • Anti-acne

Anti-acne activity can be determined from anti-microbial activity of test substances against acne-related microorganisms. 

  • Anti-aging

Anti-aging activity of test substances can be evaluated from various assays, such as anti-elastase and anti-collagenase testing.

  • UV protection

UV protection or photoprotection property of test substances can be determined in vitro using cultured cells or tissues.



Microbiology testing

 

Method

Standard

Scope

Material tested

Antibacterial activity assessment of textile materials: Parallel streak method

AATCC 147

Qualitative

Textile materials

Testing for antibacterial activity and efficacy on textile products: clear zone method    

JIS L 1902

Qualitative

Textile materials

Antimicrobial disk susceptibility tests     

CLSI M02-A11

Qualitative

Liquid samples

Assessment of antibacterial finishes on textile materials

AATCC 100

Quantitative

Textile materials

Testing for antibacterial activity and efficacy on textile products: reduction of viability    

JIS L 1902

Quantitative

Textile materials

Antibacterial products –Test for antimicrobial activity and efficacy    

JIS Z 2801

Quantitative

Plastics and other non-porous surfaces of products

Standard test method for determining the antimicrobial activity of immobilized antimicrobial agents under dynamic contact conditions    

ASTM E 2149

Quantitative

Non-soluble solid materials

Determination of minimal inhibitory concentrations of aerobic bacteria    

CLSI M07-A9

Quantitative

Liquid samples

Measurement of antibacterial activity on plastics and other non-porous surfaces    

ISO 22196

Quantitative

Plastic and other non-porous surfaces of products


Strains of bacteria

Gram positive

Staphylococcus aureus ATCC 6538  

Staphylococcus aureus ATCC 6538P

Staphylococcus aureus ATCC 25923

Gram negative

Escherichia coli ATCC 8739 

Escherichia coli ATCC 25922

Klebsiella pneumoniae ATCC 4352  

Klebsiella pneumoniae ATCC 700603

Pseudomonas aeruginosa ATCC 15442

Pseudomonas aeruginosa ATCC 27853

Salmonella enterica ATCC 10708